Discover Applications of peripheral blood mononuclear cells in research?
Peripheral Blood Mononuclear Cells (PBMCs) are a group of blood cells such as lymphocytes (T-cells, B-cells and NK cells), monocytes, and dendritic cells that play an essential role in modulating immunity in humans. It is also known as agranulocytes. PBMCs defend the body against cancer and other human pathogenic diseases and infections.
How are Peripheral Blood Mononuclear Cells produced?
Peripheral Blood Mononuclear Cells are produced from haematopoietic stem cells in the bone marrow by the process of haemopoiesis. During hematopoiesis, the cells differentiate to form distinct lineages called myeloid and lymphoid. PBMCs are released into the peripheral bloodstream to promote immunity; they normally contain rounded single-nucleated lymphoid cells and specific myeloid cells. In the fight against bacteria, viruses, fungi, and other external invaders of the human body, these cells serve as the immune system's main engine. PBMCs serve as our body's first line of defence.
Application of PBMC in Biomedical Research
The PBMC is thought to be the foundation and regulating element of the human immune system. Blood samples, usually peripheral blood mononuclear cells, have been used a lot in recent years for many types of biomedical research purposes, such as:
Precision medicine research
Vaccine research
Toxicological studies
Pharmacological research
Infectious disease research
Oncology research and treatment
Blood biomarker studies
In-vitro human disease modelling
In-vitro diagnostics research and more
Therefore, speeding up PBMC research contributes to discovering new areas of biological study.
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