CentraBiohub

  A snapshot of the present clinical research landscape. Healthcare and diagnostics research has gained momentum in the past century, with researchers worldwide striving to discover new and cost-effective clinical trial methods without compromising quality. With growing competition among pharmaceutical companies, there is a pressing need to increase the volume of clinical research and trials. Clinical trials that involve human participants are riskier and more expensive for sponsors. Additionally, enrolling the appropriate study group, retaining participants from study start to finish, and conducting prospective follow-ups can pose significant challenges and cost cumbersome. Human biospecimens, such as serum, plasma, urine, CSF, stool, and tissue collected from patients, can serve as in-vitro human models for clinical research developments in this context. These biospecimens can provide valuable insights into the biology of diseases and their response to treatments without the comp...

  Alzheimer's is a neurological disorder characterized by brain atrophy that can lead to severe memory loss. It is the leading cause of dementia worldwide, as patients gradually lose their cognitive abilities and other mental skills, eventually becoming unable to function independently. While family history and advancing age are among the most significant risk factors for Alzheimer's disease, its specific cause remains uncertain. Nevertheless, it is a major illness associated with ageing and impacts millions of individuals globally. Alzheimer's disease causes Research efforts are underway globally to uncover the precise aetiology of Alzheimer's disease. Nonetheless, the most prominent determinant influencing disease progression is age, as individuals over 65 are at a greater risk of developing the condition than younger adults. Additionally, having a family history of the disease is strongly associated with its incidence. Other extrinsic factors, such as diet, lifestyle...

  Parkinson's disease is a condition that can severely impact a person's life. It causes a range of symptoms, including shaking, stiffness, difficulty balancing, and coordination issues. This disease is caused by the death of specific neurons in the brain, which leads to the formation of Lewy bodies and motor impairment. The condition is also known as parkinsonism. Despite many years of research, we still need to understand the cause of this disease fully. Unfortunately, the prevalence of Parkinson's disease is on the rise, making it more important than ever to find better diagnostic tests and effective treatments. What are Parkinson's disease symptoms? Parkinson's disease is a progressive disorder with symptoms worsening over time. Early signs of Parkinson's disease include tremors while at rest, rigid limbs and trunks, slow movement, and balance problems. As the disease advances, individuals may experience difficulty with swallowing, walking, standing, and sit...

  Peripheral Blood Mononuclear Cells (PBMCs) are a group of blood cells such as lymphocytes (T-cells, B-cells and NK cells), monocytes, and dendritic cells that play an essential role in modulating immunity in humans. It is also known as agranulocytes. PBMCs defend the body against cancer and other human pathogenic diseases and infections. How are Peripheral Blood Mononuclear Cells produced? Peripheral Blood Mononuclear Cells are produced from haematopoietic stem cells in the bone marrow by the process of haemopoiesis. During hematopoiesis, the cells differentiate to form distinct lineages called myeloid and lymphoid. PBMCs are released into the peripheral bloodstream to promote immunity; they normally contain rounded single-nucleated lymphoid cells and specific myeloid cells. In the fight against bacteria, viruses, fungi, and other external invaders of the human body, these cells serve as the immune system's main engine. PBMCs serve as our body's first line of defence. Applica...

  Today, human tissue banking offers a wide range of opportunities and is essential to contemporary medical research. The specialized, licensed facilities known as tissue banks gather, process, store, and distribute human tissues for clinical transplantation, medical research, and educational purposes. Tissue banking is an idea that is as old as skin grafting itself. Typically, human tissues specimens for banking are obtained from the human body while the patient is still alive during a clinical procedure, a biopsy, or surgery. The tissue samples may occasionally be taken from individuals who have died. After being examined, the collected human tissues are prepared for usage in sterile cryogenic units by processing and preserving them in tissue banks. Additionally, rigorous quality control is used to preserve the integrity of the samples and stop tissue damage due to natural processes like necrosis and apoptosis.   Use of Human Tissue Samples This age has seen a rise in the ac...

  A biobank is a specialised facility that gathers, preserves and distributes priceless human biospecimens with associated data for clinical and experimental research. It also goes by the name "biorepositories."  It is two types based on ownership and governance ie, public biobanks and commercial biobanks. Public biobanks own by governmental biomedical research organisations, universities or non-profitable research centres. On the other hand, commercial biobanks are owned by CROs and other profitable organisations. Let us see what exactly are human biospecimens or human samples. Any substances derived from the patient or consented donors, such as blood, urine, tissues, organs, cells, DNA, hair, teeth, bones, etc., gathered during clinical procedures such as treatment or diagnosis are referred to as human biomaterials or human biological materials. Human biobanks are specially constructed facilities where the collected human specimens are obtained for diagnostic and medici...

  The COVID-19 pandemic affected nearly every aspect of the lives of people worldwide. Caused by a virus outbreak in December 2019, the coronavirus SARS-CoV-2 has since then posed a significant threat to global health. Due to the rapid development and distribution of COVID-19 vaccines, this devastating disease could fortunately be stopped resulting in the end of the global pandemic in May 2023. COVID-19 is characterized by symptoms that range from mild respiratory issues to severe pneumonia and even take lethal courses in some cases. The virus primarily spreads through respiratory droplets exhibited by coughing and sneezing, which made mask-wearing, social distancing, and hand hygiene essential preventive measures during the pandemic. However, the most effective tool proven had been the COVID-19 vaccination which effectively led to the end of the global pandemic. COVID-19 vaccines have been with unprecedented speed due to significant advances in vaccine technology and global collab...

  Triple Negative Breast Cancer (TNBC) is a type of breast cancer that can become challenging in terms of both diagnosis and treatment. In comparison to other forms of breast cancer, TNBC lacks three crucial receptors, namely the estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2/neu).  Since these receptors are also used for breast cancer treatment, the absence of these receptor targets makes TNBC more aggressive and limits the treatment options. Therefore, new treatment approaches and diagnostic approaches are needed. The diagnosis of TNBC typically involves a combination of techniques such as mammography, ultrasound, biopsy, and immunohistochemistry. The absence of ER, PR, and HER2/neu receptors is especially confirmed through immunohistochemical tests which allow the distinguishment of TNBC from other breast cancer subtypes. However, precise diagnosis is not trivial as TNBC shares symptoms with other breast cancers as w...

  What are human biospecimens? Human biospecimens are crucial in research as they provide valuable biological material that can be used to study disease processes, test new treatments and diagnostic methods, and advance our understanding of human health and disease. It includes blood, tissue, urine, saliva, and other bodily fluids, and they can be collected from patients with a wide range of conditions, including cancer, infectious diseases, and autoimmune disorders. Human biospecimens can be analyzed to identify markers of disease, determine the presence of specific viruses or bacteria, and assess the effectiveness of new treatments. By using human bio specimens, researchers can study real-life examples of disease, making their findings more relevant and meaningful. Additionally, by collecting biospecimens from diverse populations, researchers can gain a better understanding of how diseases affect different groups of people, which can inform personalized and effective treatments. ...

  Disease incidence and prevalence have reached unprecedented heights in today's fast-changing world, driving up the demand for cutting-edge medical research to develop the next generation of treatments and diagnostics for better disease management. Any medical discovery begins with human biosamples collected from patients. To advance studies and accomplish study targets, researchers must gather compatible human specimens from the target population, including healthy donors and patients, in the right quantity and quality. Ironically, this is frequently the most time-consuming part of the entire research process. After spending extra time looking for study specimens, researchers often come up with nothing. On the other hand, human biological materials are accumulating in several biobanking facilities without being used for any research. What is the solution for this? Knowing this to be accurate, we decided to streamline the acquisition of biological specimens. Therefore, we introduc...

  What Exactly is a Biorepository? A biobank, often referred to as a biorepository, is a facility specifically designed to house human specimens and related data for research. It is a collection of numerous human samples that are yet to be studied in order to produce the latest in human diagnostic and medical technology. Biorepositories' primary duties include gathering, processing, storing, and disseminating priceless human biospecimens for scientific study. Biobanks preserving samples for a long years without compromising their quality and integrity. Role of human biospecimens for research Modern clinical research prioritizes increased studies on a variety of genetically varied human samples due to pressing need for individualized therapy. This aids scientists in comprehending the precise causes, course, and effects of diseases, as well as any variations brought on by interindividual differences. To support successful research endeavors, it is crucial to have access to high-quali...

  Hashimoto's thyroiditis, also known as chronic autoimmune thyroiditis, is a persistent autoimmune disorder that affects the normal functioning of the thyroid gland. It is caused by the abnormal immunological processes known as cell- or antibody-mediated destroy the healthy cells of the thyroid gland, resulting in increased fibrosis and a decrease in the synthesis and release of thyroid hormones into the bloodstream. The underlying causes of this autoimmune condition are not fully understood, and ongoing research is underway worldwide to understand the disease's pathophysiology and triggers. Know the symptoms of Hashimoto's disease. Hashimoto's thyroiditis is a leading cause of autoimmune thyroiditis or hypothyroidism in developed countries. This condition impairs the normal production and synthesis of thyroid hormones, leading to low levels in the blood and decreased ability to maintain normal body metabolism. The early stages of the disease often show a slow progress...