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Order high - quality liver disease biospecimens online - Central BioHub

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  A snapshot of the present clinical research landscape. Healthcare and diagnostics research has gained momentum in the past century, with researchers worldwide striving to discover new and cost-effective clinical trial methods without compromising quality. With growing competition among pharmaceutical companies, there is a pressing need to increase the volume of clinical research and trials. Clinical trials that involve human participants are riskier and more expensive for sponsors. Additionally, enrolling the appropriate study group, retaining participants from study start to finish, and conducting prospective follow-ups can pose significant challenges and cost cumbersome. Human biospecimens, such as serum, plasma, urine, CSF, stool, and tissue collected from patients, can serve as in-vitro human models for clinical research developments in this context. These biospecimens can provide valuable insights into the biology of diseases and their response to treatments without the comp...
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What are the causes of Alzheimer's disease

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  Alzheimer's is a neurological disorder characterized by brain atrophy that can lead to severe memory loss. It is the leading cause of dementia worldwide, as patients gradually lose their cognitive abilities and other mental skills, eventually becoming unable to function independently. While family history and advancing age are among the most significant risk factors for Alzheimer's disease, its specific cause remains uncertain. Nevertheless, it is a major illness associated with ageing and impacts millions of individuals globally. Alzheimer's disease causes Research efforts are underway globally to uncover the precise aetiology of Alzheimer's disease. Nonetheless, the most prominent determinant influencing disease progression is age, as individuals over 65 are at a greater risk of developing the condition than younger adults. Additionally, having a family history of the disease is strongly associated with its incidence. Other extrinsic factors, such as diet, lifestyle...
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What are the effects of Parkinson disease

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  Parkinson's disease is a condition that can severely impact a person's life. It causes a range of symptoms, including shaking, stiffness, difficulty balancing, and coordination issues. This disease is caused by the death of specific neurons in the brain, which leads to the formation of Lewy bodies and motor impairment. The condition is also known as parkinsonism. Despite many years of research, we still need to understand the cause of this disease fully. Unfortunately, the prevalence of Parkinson's disease is on the rise, making it more important than ever to find better diagnostic tests and effective treatments. What are Parkinson's disease symptoms? Parkinson's disease is a progressive disorder with symptoms worsening over time. Early signs of Parkinson's disease include tremors while at rest, rigid limbs and trunks, slow movement, and balance problems. As the disease advances, individuals may experience difficulty with swallowing, walking, standing, and sit...
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Discover Applications of peripheral blood mononuclear cells in research?

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  Peripheral Blood Mononuclear Cells (PBMCs) are a group of blood cells such as lymphocytes (T-cells, B-cells and NK cells), monocytes, and dendritic cells that play an essential role in modulating immunity in humans. It is also known as agranulocytes. PBMCs defend the body against cancer and other human pathogenic diseases and infections. How are Peripheral Blood Mononuclear Cells produced? Peripheral Blood Mononuclear Cells are produced from haematopoietic stem cells in the bone marrow by the process of haemopoiesis. During hematopoiesis, the cells differentiate to form distinct lineages called myeloid and lymphoid. PBMCs are released into the peripheral bloodstream to promote immunity; they normally contain rounded single-nucleated lymphoid cells and specific myeloid cells. In the fight against bacteria, viruses, fungi, and other external invaders of the human body, these cells serve as the immune system's main engine. PBMCs serve as our body's first line of defence. Applica...
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What are tissue banks, and how are they used?

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  Today, human tissue banking offers a wide range of opportunities and is essential to contemporary medical research. The specialized, licensed facilities known as tissue banks gather, process, store, and distribute human tissues for clinical transplantation, medical research, and educational purposes. Tissue banking is an idea that is as old as skin grafting itself. Typically, human tissues specimens for banking are obtained from the human body while the patient is still alive during a clinical procedure, a biopsy, or surgery. The tissue samples may occasionally be taken from individuals who have died. After being examined, the collected human tissues are prepared for usage in sterile cryogenic units by processing and preserving them in tissue banks. Additionally, rigorous quality control is used to preserve the integrity of the samples and stop tissue damage due to natural processes like necrosis and apoptosis.   Use of Human Tissue Samples This age has seen a rise in the ac...
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Biobanks are Core Resource for Modern Clinical Research

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  A biobank is a specialised facility that gathers, preserves and distributes priceless human biospecimens with associated data for clinical and experimental research. It also goes by the name "biorepositories."  It is two types based on ownership and governance ie, public biobanks and commercial biobanks. Public biobanks own by governmental biomedical research organisations, universities or non-profitable research centres. On the other hand, commercial biobanks are owned by CROs and other profitable organisations. Let us see what exactly are human biospecimens or human samples. Any substances derived from the patient or consented donors, such as blood, urine, tissues, organs, cells, DNA, hair, teeth, bones, etc., gathered during clinical procedures such as treatment or diagnosis are referred to as human biomaterials or human biological materials. Human biobanks are specially constructed facilities where the collected human specimens are obtained for diagnostic and medici...
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How the COVID-19 vaccines changed the course of the pandemic

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  The COVID-19 pandemic affected nearly every aspect of the lives of people worldwide. Caused by a virus outbreak in December 2019, the coronavirus SARS-CoV-2 has since then posed a significant threat to global health. Due to the rapid development and distribution of COVID-19 vaccines, this devastating disease could fortunately be stopped resulting in the end of the global pandemic in May 2023. COVID-19 is characterized by symptoms that range from mild respiratory issues to severe pneumonia and even take lethal courses in some cases. The virus primarily spreads through respiratory droplets exhibited by coughing and sneezing, which made mask-wearing, social distancing, and hand hygiene essential preventive measures during the pandemic. However, the most effective tool proven had been the COVID-19 vaccination which effectively led to the end of the global pandemic. COVID-19 vaccines have been with unprecedented speed due to significant advances in vaccine technology and global collab...
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