What are peripheral blood mononuclear cells and their functions?
Peripheral Blood Mononuclear Cells, abbreviated as PBMCs, refer to a group of human blood cells such as lymphocytes (T-cells, B-cells and NK cells), monocytes, and dendritic cells that play an essential role in human immunity. It is also known as agranulocytes. PBMCs protect the body from human pathogenic infections and diseases, including cancers. How are Peripheral Blood Mononuclear Cells produced? Peripheral Blood Mononuclear Cells are produced from haematopoietic stem cells in the bone marrow by haemopoiesis. During hematopoiesis, the cells differentiate to form distinct lineages called myeloid and lymphoid. PBMC typically include rounded single nucleated lymphoid cells and specific myeloid cells and are released into the peripheral bloodstream to provide immunity. These cells act as the key driver of the human immune system to fight against bacteria, viruses, funguses and other foreign substances attacking the human body. PBMCs are the defensive line of our body. Applications of P...